can omeprazole cause neuropathy
These side effects may go away during treatment as your body adjusts to the medicine. https://www.nature.com/articles/s41598-019-53622-3#:~:text=While%20the%20direct%20correlation%20with,compared%20to%208%2C309%20H2RA%20patients. Prescription omeprazole comes as DR capsules in strengths of 10 mg, 20 mg, and 40 mg. Omeprazole DR 40-mg can cause the same types of side effects as the other strengths. Steve P. Interested in more discussions like this? Do not take these drugs with omeprazole. You may report them to the FDA. Talk with your doctor about whether omeprazole is safe for you. MeSH It seems like my later doctors never want to take on questioning or changing what (now deceased) doctors did, and everything we do is just moving forward with new additions of drugs. If you stop taking the drug suddenly or dont take it at all: Your acid reflux, heartburn, or ulcer symptoms may not improve. Taking it again could be fatal (cause death). Accessed March 26, 2019. Having low magnesium levels can be serious. However, if the side effects last longer than that, bother you, or become severe, be sure to talk with your doctor or pharmacist. For people with osteoporosis: People who take multiple doses of this drug every day for a year or longer may have an increased risk of fractures. Talk to your doctor if youre pregnant or planning to become pregnant. Examples of these drugs include: Disclaimer: Our goal is to provide you with the most relevant and current information. Symptoms often include tingling or numbness (first in the toes and fingers), weakness of the arms and legs, loss of deep tendon reflexes, fatigue, and abnormal sensations. The most common causes for neuropathic pain can be divided into four main categories: disease, injury, infection, and loss of limb. Lightheadedness occurred predominantly in severely ill or elderly patients. Learn about them here. For people with low magnesium levels in the blood: This drug can cause low magnesium levels if youve been taking it for three months or longer. Dont take this drug again if youve ever had an allergic reaction to it or other proton pump inhibitors. - MedShadow Foundation | Independent Health & Wellness Your dosage, drug form, and how often you take the drug will depend on: This drug hasnt been studied in children. However, if your symptoms are serious and you think youre having a medical emergency, immediately call 911 or your local emergency number. You could try from the beginning by taking the Prilosec again for a few days until the worst discomfort is over. Epub 2020 Feb 27. Our team thoroughly researches and evaluates the recommendations we make on our site. Long-term use of omeprazole can increase your risk of the following side effects: If your doctor prescribes omeprazole for a long time, they may order blood tests to check your magnesium and vitamin B12 levels. It is created by eHealthMe based on reports of 54,594 people who have side effects when taking Naproxen from the FDA, and is updated These are just a few of the more common side effects reported by people who took omeprazole capsules or tablets in clinical trials: * For more information about this side effect, see the Omeprazole: Side effect specifics section below. I stopped the prosilec abruptly..I know now it was not the right choice but I do not want to take it ..was on the med for over 6 years..I am taking pepcid and fgard..but still having rebound acid..I will go get gaviscon and try that..hopefully it will get betterthank you for the information. Gabapentin for chronic neuropathic pain and fibromyalgia in adults. They may want to investigate possible causes. Accessed March 27, 2019. Do Statins Produce Neurological Effects Possibly. Side effects from other drugs: Taking omeprazole with certain medications raises your risk of side effects from these drugs. Examples of these drugs include: Saquinavir. Omeprazole may greatly increase the levels of saquinavir in your body. Your doctor may lower your dose of saquinavir. Digoxin. Anyway, today I've decided I will stop taking my PPI (and I will send my PCP & GI a note since I don't see them for 6 months). In: Integrative Medicine. The .gov means its official. Goldman L, et al., eds. They may even get worse. I have been on a goal to reduce my medicine list, especially for "fuzzy" things. They can investigate the possible cause and suggest ways to maintain a weight that is healthy for you. National Institute of Neurological Disorders and Stroke. Heartburn can cause a variety of sensations, such as burning in the throat and pressure on the chest. Are you better after stopping the PPIs? * Delayed release means the active ingredient is not released until it passes through your stomach. Before Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. 2022 Nov 14;12(11):e062198. Has anyone here ever had a neuropathy they believed to be linked to PPI use? Again, after another 2-week period, if you have no more acid rebound symptoms, then you can stop taking your Prilosec. Diarrhea was one of the more common side effects reported in clinical trials of omeprazole capsules. Can omeprazole cause One of the most common causes is diabetes. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. If that happens, I can either re-start the PPI or try Pepcid for a while. This could lead to weight loss. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. [Ref], Rare (0.01% to 0.1%): Interstitial nephritis, Very rare (less than 0.01%): Impaired renal function, nephrosis, Postmarketing reports: Elevated serum creatinine, glycosuria[Ref], Frequency not reported: Irreversible visual impairment, Postmarketing reports: Anterior ischemic optic neuropathy, double vision, dry eye syndrome, ocular irritation, optic atrophy, optic neuritis[Ref], Irreversible visual impairment has been reported in critically ill patients who generally received high doses of the IV formulation as a bolus; however, no causal relationship has been established. Alternatives to Proton Pump Inhibitors (PPIs) for GERD HHS Vulnerability Disclosure, Help Bull. People of Asian descent: Your doctor may give you a lower dosage of this medication, especially if youre taking it for erosive esophagitis. 2014 Apr 27;2014(4):CD007938. Prilosec and Peripheral neuropathy, a phase IV clinical study of Thank you! The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that youre taking. eCollection 2023. PriLOSEC (omeprazole)." * For details about nausea and diarrhea with omeprazole, see the Omeprazole: Side effect specifics section below. Your doctor can also tell you more about omeprazole. Also had a recent bout of diarrhea coming and going for the last 6 weeks. This was among the more common side effects reported in clinical trials of omeprazole capsules. Carpal tunnel syndrome is an example of mononeuropathy. Peripheral neuropathy risk factors include: Complications of peripheral neuropathy can include: The best way to prevent peripheral neuropathy is to manage medical conditions that put you at risk, such as diabetes, alcoholism or rheumatoid arthritis. Conclusion: It could also worsen symptoms of the condition youre taking omeprazole to treat. Available for Android and iOS devices. Mayo Clinic. Omeprazole Delayed-Release Capsules and Tablets (OTC), redness, tenderness, itching, burning, or peeling of the skin, sores, ulcers, or white spots on the lips, in the mouth, or on the genitals, blistering, peeling, or loosening of the skin, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, muscle cramps in the hands, arms, feet, legs, or face, pain or swelling in the arms or legs without any injury, pains in the stomach, side, or abdomen, possibly radiating to the back, puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, red skin lesions, often with a purple center, continuing ringing or buzzing or other unexplained noise in the ears, increased sensitivity of the skin to sunlight, redness or other discoloration of the skin, swelling of the breasts or breast soreness in both females and males. What foods should I avoid when taking omeprazole? WebThe phase IV clinical study analyzes which people take Omeprazole and have Peripheral sensory neuropathy. The Foundation for Peripheral Neuropathy. Kachrani R, Santana A, Rogala B, Pawasauskas J. J Pain Palliat Care Pharmacother. WebPeripheral neuropathy is found among people who take Naproxen, especially for people who are male, 60+ old. You can use the study as a second opinion to make health care decisions. All rights reserved. Your doctor may prescribe antibiotics or other treatments if you have diarrhea caused by a C. diff infection. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Nexium vs Prilosec: What's the difference between them? Neuropathy associated with lansoprazole treatment It comes with serious risks if you dont take it as prescribed. They may recommend taking a laxative medication or other measures to ease the problem. I have had night sweats, facial itching, had and feet numbness and tingling, then even some imbalance and stumbling. Is omeprazole (Prilosec) bad for your kidneys? This condition may be a manifestation of the underlying condition, which is known to be associated with tumors.[Ref]. WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health. AskMayoExpert. Moore RA, Wiffen PJ, Derry S, Toelle T, Rice AS. Cochrane Database Syst Rev. Early diagnosis and treatment offer the best chance for controlling your symptoms and preventing further damage to your peripheral nerves. Can diet help improve depression symptoms? Omeprazole belongs to a class of drugs called proton pump inhibitors (PPIs). Make your tax-deductible gift and be a part of the cutting-edge research and care that's changing medicine. Its important to note that if you take omeprazole with antibiotics, you may have an increased risk of this type of diarrhea. To learn about the dosages of omeprazole, see this article. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. Pharmacol. Liver problems. Hypokalemia was reported in pediatric patients. Orange Book: Approved drug products with therapeutic equivalence evaluations. Peripheral neuropathy is nerve damage caused by a number of different conditions. Vilholm OJ, Christensen AA, Zedan AH, Itani M. Basic Clin Pharmacol Toxicol. The Foundation for Peripheral Neuropathy. It seems like there is definitely a chance the two are connected but I have never spoke with anyone else who has made the connection. Nausea can also be a symptom of the conditions omeprazole is used to treat. tingling, prickling, or burning sensations, skin rash, especially on skin often exposed to the, eat small amounts frequently, rather than eating large main meals, eat in small amounts frequently, rather than eating large main meals, swelling under your skin, typically in your eyelids, lips, hands, or feet, swelling of your mouth, tongue, or throat, which can make it hard to breathe. Your peripheral nervous system sends information from your brain and spinal cord (central nervous system) to the rest of your body. If you had an ulcer when you started medication, you may also need 20 mg once daily for an additional 14 days. O 0. WebAbstract. @piross1528 I don't know if you've come across this paper, but thought I'd share in case it helps you as you continue to explore the connection. Philadelphia, Pa.: Elsevier; 2018. https://www.clinicalkey.com. charithran8975 Yes, omeprazole can cause neuropathy. Furthermore, we found significant associations of PPI use with a wide range of neurological adverse reactions including, migraine, several peripheral neuropathies, As with all medications, the costs of omeprazole can vary. Matta C, Meyer L, Mensah-Nyagan AG, Taleb O. Neurotox Res. The drug has been in use for some 10 years and appears to be safe for long term use. Hemorrhagic necrotic gastritis has been reported in pediatric patients. Serious side effects that have been reported and their symptoms include: * For more information about this side effect, see the Omeprazole: Side effect specifics section below. However, its not clear whether this side effect occurred in clinical trials of omeprazole capsules or tablets. If you have trouble swallowing a capsule, you can open it and empty its contents (pellets) onto 1 tablespoon of applesauce. Most people with peripheral neuropathy have polyneuropathy. This study aimed to explore the possible association between PPIs use and ADs.MethodsThis study was Contact your doctor if you have diarrhea thats severe or doesnt go away. GERD (persistent acid reflux): Symptoms, treatments, and causes. This helps prevent the drug from being deactivated by the acid in your stomach. Other medications. Gomm et al. [Ref], Postmarketing reports: Gastroduodenal carcinoids[Ref], Gastroduodenal carcinoids have been reported in patients with Zollinger-Ellison syndrome on long-term therapy. The authors noted that two German studies have previously reported an increased risk of dementia (hazard ratio 1.38-1.44) in older PPI users (Haenisch et al. Be sure to tell your doctor or pharmacist about other drugs that you take.Omeprazole can interact with certain other medications. Some people may have nausea while taking omeprazole. Peripheral neuropathy fact sheet. Symptoms of peripheral neuropathy. Its not clear whether this side effect occurred in clinical trials of omeprazole tablets. Read on to learn about potential common, mild, and serious side effects. Keep it in your carry-on bag. If these effects are mild, they may go away within a few days or a couple of weeks. The Foundation for Peripheral Neuropathy. You may need to decide whether to stop breastfeeding or stop taking this medication. Side Effects of Zegerid (Omeprazole, Sodium Bicarbonate), Would you like email updates of new search results? It doesnt have a brand-name version. Specifically, you may have an increased risk of bone fractures (breaks) and a low vitamin B12 level if you take a high dosage of omeprazole. Always carry the original prescription-labeled container with you. The study compared adverse events in patients receiving monotherapy with either a proton pump inhibitor (n=42,537) or an H2-receptor blocker (e.g. Accessed March 25, 2019. If you have one of these conditions, talk with your doctor about whether omeprazole is safe for you. Applies to omeprazole: oral capsule delayed release, oral packet, oral powder for suspension, oral tablet disintegrating delayed release, oral tablet delayed release. OTC omeprazole is used short term. I can contend with the crazy pain and numbness during the day because I stay physically active, I don't have a rocking chair! Omeprazole oral capsule is used to reduce the amount of acid in your stomach. Along with its needed effects, omeprazole/sodium bicarbonate may cause some unwanted effects. Any medical information published on this website is not intended as a substitute for informed medical advice and you should not take any action before consulting with a healthcare professional. Learn more about GER and burping here. Last medically reviewed on October 5, 2022. Although not all of these side effects may occur, if they do occur they may need medical attention. It shouldnt be used in this age group. All rights reserved. It hurts getting off ppi..I am doing it now..stopped the priolsec and taking pepcid for the horrible burning ..doctors tell you to take ppi Most peoples body weight fluctuates over time, but rapid weight gain can sometimes indicate a medical issue. Be sure to avoid doing this when the weather is very hot or very cold. If your child has been prescribed omeprazole and youre concerned about side effects, talk with their doctor. This content does not have an Arabic version. eHealthMe is studying from 360,065 Omeprazole users for its effectiveness, alternative drugs and more. Proton-pump inhibitor use is associated with a broad spectrum of neurological adverse events including impaired hearing, vision, and memory: Learn more about them here. information submitted for this request. Omeprazole oral capsule can interact with other medications, vitamins, or herbs you may be taking. https://www.foundationforpn.org/what-is-peripheral-neuropathy/evaluation-and-tests/. Seek medical care right away if you notice unusual tingling, weakness or pain in your hands or feet. If you have constipation while taking omeprazole, it will typically get better in a few days or weeks. Peripheral neuropathy (adult). MNT is the registered trade mark of Healthline Media. If you miss doses or dont take the drug on schedule: Your medication may not work as well or may stop working completely. Note that constipation could be a symptom of a low vitamin B12 level, which may be associated with long-term use of omeprazole. Gastroesophageal reflux (GER) can cause a person to belch. Omeprazole oral capsule is used for short-term treatment of duodenal and gastric ulcers and gastroesophageal reflux disease (GERD). Neurobiol. Hepatic encephalopathy occurred in patients with preexisting liver disease. Gastroesophageal reflux disease (GERD) is long-term, regular acid reflux. If you have diarrhea while taking omeprazole, it will typically get better in a few days or weeks. Publication types Case Reports MeSH terms Aged (Omeprazole belongs to the proton pump inhibitor drug class.) Check whether Peripheral sensory neuropathy is associated with a drug or a condition, Peripheral sensory neuropathy in Omeprazole, Peripheral sensory neuropathy and drugs with ingredients of omeprazole, Peripheral sensory neuropathy in Moderna COVID Vaccine, Peripheral sensory neuropathy in Pfizer BioNTech Covid Vaccine, Peripheral sensory neuropathy in Johnson and Johnson Covid Vaccine, Methotrexate and Psorcon drug interaction. 8 It, along with sulfa analogs such as sulfanilamide (AVC), acetazolamide (Diamox) and hydrochlorothiazide (Oretic), has been shown to cause induced bilateral myopia and anterior chamber Then start the slow taper. A 12-year-old girl with no psychiatric history developed psychotic symptoms, including formal thought disorder and delusional ideas after omeprazole was initiated. Responds to IVIG but wondering if I just need to quit the PPI. Omeprazole (oral forms) side effects: How to manage them Low magnesium levels can be associated with long-term use of PPIs These include an allergic reaction to omeprazole, any of its ingredients, or other proton pump inhibitor drugs. As with most drugs, omeprazole can cause an allergic reaction in some people. Call 911 if your symptoms feel life-threatening or if you think youre having a medical emergency. Background Oxaliplatin causes acute cold-induced neurotoxicity and chronic cumulative neuropathy, which can require dose modification and impacts quality of life. Be sure to talk with your doctor about your health history before you take omeprazole. Peripheral neuropathy care at Mayo Clinic. If you had an ulcer when you started medication, you may also need 20 mg once daily for an additional 18 days. We avoid using tertiary references. [Ref], Postmarketing reports: Hematuria, microscopic pyuria, proteinuria, testicular pain, urinary frequency, urinary tract infection[Ref], A causal relationship between this drug and impotence has not been established. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Stomach or abdominal pain may be related to other side effects of omeprazole, such as constipation, diarrhea, or gas. https://www.foundationforpn.org/what-is-peripheral-neuropathy/. If you drink alcohol, talk with your doctor about how much, if any, is safe to consume while youre taking omeprazole. Peripheral neuropathy is a painful condition deriving from many and varied etiologies. Some may be better suited for you than others. -, Ma J., Kavelaars A., Dougherty P.M., Heijnen C.J. Behavioral, Electrophysiological, and Histological Characterization of a New Rat Model for Neoadjuvant Chemotherapy-Induced Neuropathic Pain: Therapeutic Potential of Duloxetine and Allopregnanolone Concomitant Treatment. This information is not a substitute for medical advice. WebResults: Drug-induced peripheral neuropathy is a common and painful condition caused by many different and frequently prescribed medications. Omeprazole DR 40-mg can cause the same types of side effects as the other strengths. Omeprazole can cause a severe allergic reaction. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, Omeprazole: 20-mg vs. 40-mg strength side effects, https://www.ncbi.nlm.nih.gov/books/NBK100895/, https://nctr-crs.fda.gov/fdalabel/services/spl/set-ids/afda9d2c-b141-4c32-a5b4-e850974b30a3/spl-doc, https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=fb3b1c3b-d486-4fa6-9ebf-ee1812ed2512, https://www.accessdata.fda.gov/scripts/cder/ob/index.cfm, https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/022056s025lbl.pdf, https://nctr-crs.fda.gov/fdalabel/services/spl/set-ids/677f8593-7488-4fd8-94e7-103c743b00ea/spl-doc, New clues to slow aging? If it does nothing to reduce my PN discomfort, at least I might find out after 10 years if I really have acid reflux! You need stomach acid to absorb vitamin B-12. doi: 10.1002/14651858.CD007938.pub3. I had some very similar symptoms in 2018I stopped taking the PPI and they resolved. Neuropathic Pain: Causes, Symptoms, and Treatment Its important to drink plenty of fluids to avoid getting dehydrated. Its not known whether this may cause side effects in a child whos breastfed. Omeprazole may cause serious side effects. If youre concerned about your dosage and any possible side effects, talk with your doctor. If you have nausea while taking omeprazole, it will typically get better in a few days or weeks. They can help answer any questions you have about side effects of taking the drug. Its not clear whether this side effect occurred in clinical trials of omeprazole tablets. Dont chew or crush the capsules. Omeprazole and Peripheral sensory neuropathy - a phase I am experiencing symptoms of SFN and am wondering if anyone has ever made this connection, had this experience, or heard of such a thing. The production of stomach acid is decreased by omeprazole. Dont chew or crush the pellets. information and will only use or disclose that information as set forth in our notice of If youd like to take medications to treat diarrhea, be sure to talk with your doctor first. 2020 Jun;38(1):145-162. doi: 10.1007/s12640-020-00176-2. Percentages represent the proportion of all adverse events reported in monotherapy patients rather than incidence rates. Symptoms can be mild or serious and can include: For mild symptoms of an allergic reaction, call your doctor right away. Medical News Today only shows you brands and products that we stand behind. O 0, 5. Stomach or abdominal pain may occur while taking omeprazole. If you take too much: You could have dangerous levels of the drug in your body. A review earlier this also raised concerns about the widespread use of PPIs, which are available over-the-counter in many countries, and the possible neurological sequelae associated with chronic PPI use (Novotny et al. Zegerid (omeprazole)." Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Keep these considerations in mind if your doctor prescribes omeprazole oral capsule for you. Medications can reduce the pain of peripheral neuropathy. They may also recommend that you stop taking omeprazole. [Ref], Very common (10% or more): Taste perversion (up to 15%), Common (1% to 10%): Dizziness, drowsiness, headache, somnolence, Uncommon (0.1% to 1%): Paresthesia, taste disturbances, vertigo, Rare (0.01% to 0.1%): Hepatic encephalopathy, lightheadedness. It shouldnt be used in this age group. All information is observation-only. Prilosec (omeprazole magnesium) for delayed-release oral suspension. 2023 Jan 2;16:17562864221137129. doi: 10.1177/17562864221137129. There are other drugs available to treat your condition. The site is secure. Doing so can cause dangerous effects in the body. All possible dosages and drug forms may not be included here. Your liver is responsible for breaking down omeprazole. This information is not a substitute for medical advice. If you are a Mayo Clinic patient, this could Can Omeprazole Cause Peripheral Neuropathy neuropathy (To learn more, see the Omeprazole: Serious side effects section above.). Santarus Inc (2004): 4. In studies on patients with shingles, swelling appeared in 8% of the patients taking This delay keeps the drug from being inactivated by your stomach. Drug-Induced Peripheral Neuropathy: A Narrative Review This is the protocol I was given by my pharmacist when I was finally able to stop taking Protonix. Your doctor will write the number of refills authorized on your prescription. 25th ed. Note: Over-the-counter omeprazole tablets are not approved for use in children. Omeprazole is also available as an oral suspension and comes as an over-the-counter (OTC) medication. It is often used in gastroesophageal reflux disease. Severe hypomagnesemia may result in hypocalcemia, and this condition may be associated with hypokalemia. It comes as a prescription and over-the-counter (OTC) drug. Mild side effects that have been reported with omeprazole include: These side effects may be temporary, lasting a few days to weeks. You can learn more about how we ensure our content is accurate and current by reading our. sharing sensitive information, make sure youre on a federal The authors undertook a structured search of bibliographic databases for peer-reviewed research literature using a focused review question and inclusion/exclusion criteria. They can try to determine its cause. These drugs are often used to treat similar conditions. How soon after taking levothyroxine can I take omeprazole? If the side effects seem life threatening or you think youre having a medical emergency, immediately call 911 or your local emergency number. To learn more, see the Omeprazole: Side effect specifics section below. Fortunately, there are many natural and home remedies a person can use to get relief. If youve been taking this drug for more than three years, talk to your doctor. Your childs dosage will be based on their weight: This drug hasnt been studied in children younger than 2 years. If you have anxiety with omeprazole, talk with your doctor. Memory impairment represented 1.3% of AEs with PPIs versus 0.4% for H2 blockers. Advertising revenue supports our not-for-profit mission. People of Asian descent. Please enable it to take advantage of the complete set of features! I have been using Omeprazole (Proron pump anhibitor) for over 20 years for GERD, during the 30 years before that I ate thousands of Tums and Rolaids. Visual impairment reports (including blurred vision, loss of visual acuity and blindness) were two-fold higher with PPIs versus H2 blockers (1.6% vs. 0.8%). -Begin the taper by skipping a dose of PPIs every third day for 2 weeks. Some side effects may not be reported. Vilholm O.J., Christensen A.A., Zedan A.H., Itani M. Druginduced peripheral neuropathy. Dosage of drugs is not considered in the study. Have had peripheral neuropathy and even have been getting treated To provide you with the most relevant and helpful information, and understand which This drug hasnt been shown to be safe or effective in children younger than 1 year of age with gastroesophageal reflux disease (GERD). Taste perversion most commonly occurred in patients given concomitant treatment with clarithromycin. For a general overview of omeprazole, including details about its uses, refer to this article. "Product Information. Sensory nerves that receive sensation, such as temperature, pain, vibration or touch, from the skin, Motor nerves that control muscle movement, Autonomic nerves that control functions such as blood pressure, perspiration, heart rate, digestion and bladder function, Gradual onset of numbness, prickling or tingling in your feet or hands, which can spread upward into your legs and arms, Sharp, jabbing, throbbing or burning pain, Pain during activities that shouldn't cause pain, such as pain in your feet when putting weight on them or when they're under a blanket, Feeling as if you're wearing gloves or socks when you're not, Excessive sweating or not being able to sweat, Drops in blood pressure, causing dizziness or lightheadedness, Diabetes, especially if your sugar levels are poorly controlled, Vitamin deficiencies, particularly B vitamins, Infections, such as Lyme disease, shingles, Epstein-Barr virus, hepatitis B and C, and HIV, Autoimmune diseases, such as rheumatoid arthritis and lupus, in which your immune system attacks your own tissues, Repetitive motion, such as those performed for certain jobs.Delaware Real Estate Commission Members, Swimming Lessons For Adults Birmingham, Al, Articles C