milk thistle depression
Silymarin, a milk thistle element, is reported safe at doses of 700 milligrams three times a day for 24 weeks. However, this review also noted that the quality of the studies was not very high, so more studies are needed before its possible to make any firm recommendations (44). Tajmohammadi A, Razavi BM, Hosseinzadeh H. How Long Does It Take for Milk Thistle to Work? - LiverSupport.com Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. 5th ed. Verywell Health's content is for informational and educational purposes only. Satisfaction. More research is needed to confirm these results and the safety of milk thistle for breastfeeding mothers (38, 39, 40). Here are 10 of the best herbs for your liver, including benefits and. Depression and anxiety are associated with increased risk of developing AD. other information we have about you. Ask your doctor for advice. Keywords: and depression. Neurological Disorders Milk thistle has long been used to alleviate the inflammation commonly associated with a host of neurological disorders such as dementia, Alzheimers, and Parkinsons Disease (8). The review went on to say that silymarin may be linked to lower rates of mortality in patients with cirrhosis and liver disease. Abstract Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD). Federal government websites often end in .gov or .mil. . Interestingly, one study found that people with acne who took 210 milligrams of silymarin per day for 8 weeks experienced a 53% decrease in acne lesions (42). Milk thistle is a plant also known as Artichaut Sauvage, Cardo Lechoso, Cardui Mariae, Carduus marianus, Chardon Argent, Chardon de Marie, pine Blanche, Holy Thistle, Lady's Thistle, Lait de Notre-Dame, Legalon, Marian Thistle, Mariendistel, Mary Thistle, Shui Fei Ji, Silibinin, Silybe de Marie, Silybum, Silymarin, and other names. OCD symptoms usually revolve around irrational fears, repeated thoughts, and compulsions. There is also concern that milk thistle might affect estrogen levels. It may also make chemotherapy work more effectively against certain cancers and, in some circumstances, even destroy cancer cells (9, 29, 30, 31). Its not known whether milk thistle is helpful for other conditions. It is also unknown whether milk thistle is safe for children. This article looks at the evidence to, Whats the life expectancy of someone with cirrhosis of the liver? People mainly use the supplement to treat liver conditions. Antidepressant and Anti-anxiety Effects of Milk Thistle Unexpected effects from milk thistle. Call your doctor if the condition you are treating with milk thistle does not improve, or if it gets worse while using this product. Silymarin (Silybum marianum; SM), popularly known as milk thistle, is an extract that has been used for many centuries to treat liver diseases. Website: https://pubmed.ncbi.nlm.nih.gov/. Milk Thistle: Health Benefits, Safety Information, Dosage, and More - WebMD In some studies, silibinin, an active component of milk thistle, has been shown to have estrogen-like effects. Little is known about whether its safe to use milk thistle during pregnancy or while breastfeeding. Milk thistle is now found throughout the eastern United States, California, South America, Africa, Australia, and Asia. Milk thistle (Silybum marianum) is said to have certain health benefits, including liver health, diabetes management, cancer treatment, and more. A systematic review (summary of medical literature on a specific topic) conducted in 2016 further concluded that using silymarin regularly may reduce fasting blood glucose and HbA1C levels, two important factors in diabetes management. Milk Thistle Health Benefits: Antioxidant and Anti-inflammatory Substances in milk thistle may reduce blood sugar, a concern for people living with diabetes. This makes it very hard to establish a standard dose. Silymarin: not just another antioxidant - PubMed Consult with your healthcare provider if you experience these and other side effects to find out the best way to proceed. However, there are currently no human studies examining the effects of milk thistle in people with Alzheimers or other neurological conditions like dementia and Parkinsons. By Brittany Lubeck, RD Natural Medicines website. Read our. There are other supplements that work similarly to milk thistle. Advertising revenue supports our not-for-profit mission. In test-tube and animal studies, silymarin has been shown to prevent oxidative damage to brain cells, which could help prevent mental decline (16, 17). Other uses not proven with research have included treating malaria, mushroom poisoning, spleen or gallbladder problems, menstrual problems, liver problems (such as hepatitis B or C), and other conditions. Recent research has explored the use of milk thistle. Some of the studies have been of poor quality, too. Well go over the methods that doctors use to determine this and provide a chart, Blessed thistle is an herb with a long history of use for digestive issues and breastfeeding. By using our site, you acknowledge that you have read and understand our. Adv Ther. People sometimes use milk thistle for hepatitis C, a viral infection of the liver. People who have diabetes or endometriosis should check with a doctor before using milk thistle. Follow your healthcare provider's instructions about any restrictions on food, beverages, or activity. But the evidence is limited, and some research methodologies are flawed, so its difficult to confirm these effects. Large-scale, properly-designed studies are needed. Substances in milk thistle may reduce blood sugar, a concern for people living with diabetes. Research shows that the silymarin in milk thistle helps protect the liver from many industrial toxins, such as carbon tetrachloride. Follow all directions on the product label and package. Medically reviewed by Drugs.com on Sep 29, 2022. 2005;100(11):2583-91. doi:10.1111/j.1572-0241.2005.00262.x. 1. How Does Cirrhosis Affect Life Expectancy? information is beneficial, we may combine your email and website usage information with Accessed Oct. 30, 2020. Milk thistle is most often used for various liver conditions, like hepatitis and fatty liver disease. Similar supplements to milk thistle include: Please talk with your healthcare provider about the best supplement for you. Experts believe silymarin is the primary active ingredient of the herb. Learn. 2016;2016:5147468. doi:10.1155/2016/5147468, Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. The data is very limited, but one randomized controlled study found that mothers taking 420 mg of silymarin for 63 days produced 64% more milk than those taking a placebo (37). Milk thistle can trigger allergic reactions. Silibinin-treatment up-regulated the function through BDNF/TrkB pathway and attenuated autophagy in the hippocampus. Common side effects of milk thistle reported in studies include: Typically, side effects will subside once you stop using milk thistle. Duplication is encouraged. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). 5 Brain Supporting Supplements Youll Want In Your Medicine, According to the International OCD Foundation, selective serotonin reuptake inhibitor (SSRI), UltraThistle, the highest potency milk thistle formula, Review on the Chemistry and Neuroprotective Effects of Silymarin. National Center for Complementary and Integrative Health. Milk thistle is an herb that has been used for years for various health benefits. Learn more about natural remedies for type 2 diabetes. However, this is the only clinical study available. However, research is not conclusive on its uses. To ensure quality and potency in your herbal remedies, why not grow your own? People sometimes eat the stem and leaves of milk thistle in salads. Biomed Res Int. Milk thistlesupplementscontaining silymarin are commonly sold as teas or in capsule form, but are also available as tablets, soft gels, and liquid extracts. While not dangerous, it can cause scars. An allergic reaction is more common in people who are allergic to other plants in the Asteraceae family, such as ragweed, daisies, marigolds and chrysanthemums. JAMA. It may have protective effects on the liver, preventing damage. 1998-2023 Mayo Foundation for Medical Education and Research (MFMER). Our website is not intended to be a substitute for professional medical advice, diagnosis, or treatment. de Avelar CR, Pereira EM, de Farias Costa PR, et al. Effect of silymarin (milk thistle) on liver disease in patients with chronic hepatitis C unsuccessfully treated with interferon therapy: a randomized controlled trial. Copyright 2017 Elsevier Inc. All rights reserved. However, the review's authors warned that the quality of the studies was poor and that more research is needed before milk thistle should be recommended for use. doi:10.1002/14651858.CD003620.pub3, Gillessen A, Schmidt HH. Summary Milk thistle may help lower blood sugar levels in people with type 2 diabetes, though more high-quality studies are needed. Why does zinc cause anxiety and depression for some people? Brain Fog (anxiety, depression, ADHD), lots of medications. This publication is not copyrighted and is in the public domain. Silybum marianum (milk thistle). Thus, more studies are needed to determine what dose and length of treatment are needed for specific liver conditions (2, 11, 12). Its also unknown what doses would need to be prescribed for it to have a beneficial effect (18). eCollection 2023. 2019;33(6):1627-1638. doi:10.1002/ptr.6361. Milk Thistle (Silybum marianum) for Anxiety? Side effects are always possible when taking supplements. edeka3 Brain Fog (anxiety, depression, ADHD), lots of medications. Milk thistle may not be recommended in some situations. Learn to concoct simple home remedies with easy-to-grow medicinal herbs, Some are looking to alternative medicines to help prevent or treat diseases like cancer. Wanting to take Milk Thistle and Curcumin to alleviate OCD, Depression This prickly plant has distinctive purple flowers and white veins, which traditional stories say were caused by a drop of the Virgin Marys milk falling onto its leaves. Exercise caution and start slow. Endo-Lysosomal and Autophagy Pathway and Ubiquitin-Proteasome System in Mood Disorders: A Review Article. Milk thistle is a plant named for the white veins on its large prickly leaves. DISCUSSION: Why do I feel better with Milk Thistle? Summary The active ingredients in milk thistle have been shown in animals to improve the effects of some cancer treatments. Milk thistle is promoted as a dietary supplement for . Milk thistle has been used for a range of psychiatric disorders including methamphetamine abuse and obsessive compulsive disorder. Can You Get Milk Thistle Naturally From Foods? Malaria. There's limited evidence, though, for the role of milk thistle in bone health. Summary Milk thistle extract may help protect the liver against damage caused by disease or poisoning, though more research is needed. Amyloid plaques are sticky clusters of amyloid proteins that can build up between nerve cells as you age. Epub 2016 Dec 22. Effect of silymarin on chemical, functional, and morphological alterations of the liver. 2005 - 2023 WebMD LLC, an Internet Brands company. The following list is not exhaustive. Milk thistle can cause an allergic reaction, including a severe, potentially life-threatening allergic reaction (anaphylaxis). When reported, side effects for milk thistle are generally gut disturbances like diarrhea, nausea or bloating. These studies have also seen that milk thistle may be able to reduce the number of amyloid plaques in the brains of animals with Alzheimers disease (18, 19, 20). Therefore, it is not known whether milk thistle or silymarin should be used to treat cirrhosis. Milk thistle supplements, for . Depression is one of the most frequent psychiatric disorders of Alzheimer's disease (AD). lyndsey | nutrition + fertility + herbalism + birth on Instagram Keep in mind that supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. The Clearinghouse does not provide medical advice, treatment recommendations, or referrals to practitioners. Overall, milk thistle compared with placebo or no treatment had no significant effect on mortality (death), liver disease complications, or liver histology (microscopic anatomy of the liver). (silymarin) extract supplementation on antioxidant status and hs-CRP in patients with type 2 diabetes mellitus: a randomized, triple-blind, placebo-controlled clinical trial. A double-blind controlled study. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Careers. Now, one substance that we know can inhibit 5-alpha reductase, although it does it pretty weakly, is saw palmetto [200-500mg/Day, 2-3 . As a result, researchers suggest that milk thistle may be a useful therapy for preventing or delaying bone loss in postmenopausal women (24, 25). Minerals for OCD The survey revealed anecdotal evidence of the improved quality of life among those who took milk thistle, despite having no measurable improvements in hepatitis symptoms like liver inflammation. Disclaimer. People may also find it painful and worry about its effects on their appearance. FOIA Pizzorono JE, et al., eds. Do not use extra milk thistle to make up the missed dose. Not available for orders containing UltraNourish. Cathy Wong is a nutritionist and wellness expert. Review/update the In one clinical trial, 60 people with benign polyps in the colon (which often develop into colon cancer) took a herbal blend with milk thistle, a flaxseed antioxidant, and oat fiber for 2 . Is There a Reason Your Milk Thistle Isn't Working? JIN_FK8R Please rate my stack I know I'm Fxxked up for now. Some animal studies have shown that milk thistle could be useful for reducing the side effects of cancer treatments (26, 27, 28). Milk thistle has been used to treat disorders of the liver and gallbladder for at least 2,000 years. Milk thistle seems to have few side effects, even when taken for several years. Milk thistle is often promoted for its liver-protecting effects. People have traditionally used milk thistle for problems with the liver and gallbladder . In clinical trials, milk thistle appears to be well tolerated in recommended doses. What Are the Risks of Taking Milk Thistle? The terms "milk thistle" and "silymarin" are often used interchangeably. Milk thistle should not be used in place of medication prescribed for you by your doctor. The Physician Global Assessment and Body Surface Area composite tool is a simple alternative to the Psoriasis Area and Severity Index for assessment of psoriasis: post hoc analysis from PRISTINE and PRESTA. To provide you with the most relevant and helpful information, and understand which Milk thistle may be useful in treating liver disease, cancer, and diabetes. Bookshelf Its resources include publications (such as Dietary Supplements: What You Need To Know) and fact sheets on a variety of specific supplement ingredients and products (such as vitamin D and multivitamin/mineral supplements). This article reviews what milk thistle is and, Milk thistle tea is said to protect the liver, stimulate breast milk production, and lower blood sugar levels. It is possibly effective in diabetes and indigestion (). Phytother Res. Milk thistle is found throughout the eastern United States, California, South America, Africa, Australia, and Asia. The Gale Encyclopedia of Alternative Medicine, second edition, 2004. It may be effective in mild to moderate depression, but two studies reported no benefit in major depression . Depression. One study also found that it may slightly extend the life expectancy of people with cirrhosis of the liver due to alcoholic liver disease (10). Milk Thistle: Benefits and Side Effects - WebMD Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. National Center for Complementary and Integrative Health. Below is a short list of 4 widely available and very affordable herbs with some serious natural health benefits for OCD sufferers: Before introducing milk thistle into your diet, new supplements or any other herbs for OCD for that matter you should consult your physician. Not only does this help prevent cirrhoris, but may also be advantageous for those living with hepatitis or other liver diseases. All rights reserved. Find out more on the side effects of statins. Occasionally, people report various digestive side effects. Summary Initial test-tube and animal studies have shown that milk thistle has some promising characteristics that could make it useful for protecting brain function. Cochrane Database Syst Rev. "It helps to clear out the toxins and nourish the organ," says Justice. . And although milk thistle extract is commonly used as a complementary therapy for people with liver diseases, theres currently no evidence that it can prevent you from getting these conditions, especially if you have an unhealthy lifestyle. Before taking milk thistle, talk to your doctor, pharmacist, or health care professional if you have allergies (especially to plants), have any medical conditions, or if you take other medicines or other herbal/health supplements. Epub 2019 Nov 24. Silymarin, an active component of milk thistle, may improve liver function and reduce symptoms of cirrhosis, or scarring of the liver. You may opt-out of email communications at any time by clicking on See additional information. eCollection 2022. A study from 2012 confirmed that milk thistle might not have true beneficial effects on hepatitis C. In the study, patients who took silymarin, an active component of milk thistle, daily for 24 weeks had no significant improvements in liver enzymes or other measures compared to those who took the placebo. We comply with the HONcode standard for trustworthy health information. Its been suggested that the antioxidant effects of silymarin may have some anticancer effects, which could be helpful for people receiving cancer treatment (9). Beware that milk thistle can worsen depression, it doesn't act the same on everybody. However, there are currently no human studies, so its effectiveness remains unclear. Join 45,000+ subscribers and receive the latest, useful and exclusive health and wellness articles, health tips, special offers and more - delivered direct to your inbox. Have direct benefits against prostate, breast, and certain cervical cancer cells. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Milk Thistle: Benefits, Uses, Side Effects, and More Neuroplasticity to autophagy cross-talk in a therapeutic effect of physical exercises and irisin in ADHD. Milk Thistle Tea: Benefits, Side Effects, and Dosage - Healthline Milk thistle is a popular herbal remedy that has been used for its therapeutic effects for centuries. 2014;10(1):31-35. doi:10.17925/EE.2014.10.01.31. Fried, M.; Navarro, V.; Afdhal, N. et al. Several studies have suggested that milk thistle may be beneficial for people with type 2 diabetes. Milk thistle may interact with certain medications and supplements. In some cases it may be useful in treating these cancers, but studies have yet to fully demonstrate the safety and efficacy of milk thistle use. The study researchers hypothesize that milk thistle's antioxidant qualities make it a good candidate for treating conditions like cancer, hepatitis, NAFLD, diabetes, depression, and heart disease. Front Immunol. Its been discovered that one of the compounds in milk thistle may work similarly to some diabetic medications by helping improve insulin sensitivity and decrease blood sugar (43). Skip the missed dose if it is almost time for your next scheduled dose. The nutritional content varies for each brand, so be sure to . Summary In animals, milk thistle has been shown to stimulate bone mineralization. Other studies looking at milk thistle for cirrhosis have found conflicting results. But the herb is also believed to be beneficial for other health issues. MILK THISTLE Reviews and User Ratings: Effectiveness, Ease of - WebMD Anyone have experience with Milk Thistle for OCD/Anxiety? Benefits. Further, while liver-related mortality was significantly reduced by milk thistle, this was not seen in any of the high-quality trials. N-Acetylcysteine Milk thistle can cause: Gastrointestinal issues, such as diarrhea, constipation, nausea, vomiting and abdominal bloating Itchiness Headache If you have diabetes, use milk thistle with caution, since the supplement might lower blood sugar. Effects of Silybum marianum (L.) Gaertn. Milk thistle contains compounds that may support skin, liver, and bone health and enhance weight loss. Milk thistle has been shown in experimental test-tube and animal studies to stimulate bone mineralization and potentially be protective against bone loss (22, 23). Biomed Pharmacother. Pain in . Some medications have been known to interact with milk thistle negatively. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. If you take any medicines regularly, talk to your doctor before you start using milk thistle. Eur Endocrinol. metabolic syndrome, depression, cardiovascular diseases and thalassemia, in addition to its photoprotective activity in in vitro tests and preclinical studies. Moreover, its unclear whether milk thistle is well enough absorbed in people to allow adequate amounts to pass through the blood-brain barrier. The mention of any product, service, or therapy is not an endorsement by NCCIH. 2014;2014:941085. doi:10.1155/2014/941085. Side effects. Quality and active ingredients in supplements may vary widely from maker to maker. 7 likes, 2 comments - lyndsey | nutrition + fertility + herbalism + birth (@rooted_in_ritual) on Instagram: " Ways to Prepare for Ovulation Ovulation is the . While more research into milk thistle, silymarin, and its effectiveness in treating OCD is definitely needed, there is a wealth of information supporting the other health benefits of milk thistle for a host of ailments: Liver Health It is believed that milk thistle and silymarin bolsters liver function by prohibiting toxic substances from binding to liver cells (6). FREE standard shipping only available in the contiguous United States. 1982;17:51721. While milk thistle has been traditionally used in pregnant and breastfeeding women, its safety is unknown. National Library of Medicine (US); 2022. 5-Methyltetrahydrofolate Alleviates Memory Impairment in a Rat Model of Alzheimer's Disease Induced by D-Galactose and Aluminum Chloride. official website and that any information you provide is encrypted In fact, a recent review and analysis found that people routinely taking silymarin experienced a significant reduction in their fasting blood sugar levels and HbA1c, a measure of blood sugar control (44). However, the evidence is conflicting. More studies are needed before it can be determined how silymarin might be used to support people undergoing cancer treatment. 5 It was found that there was no significant difference between milk thistle and Prozac for OCD symptoms. New Treatments That May Change the Game, The Latest Research on Advanced Prostate Cancer. Overall, more high-quality research is needed to define the doses and clinical effects of this fascinating herb. Milk Thistle. Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. 2014;11(2):167-74. doi:10.1900/RDS.2014.11.167, Rambaldi A, Jacobs BP, Gluud C. Milk thistle for alcoholic and/or hepatitis B or C virus liver diseases. 2023 Natural Wellness. Clinical practice shows that milk thistle has a good anti-liver injury effect and can be used to prevent anti-tuberculosis drug-induced liver injury. Studies have shown improvements in liver function in people with liver diseases who have taken a milk thistle supplement, suggesting it could help reduce liver inflammation and liver damage (9). It is native to Mediterranean countries. Milk thistle might also help prevent insulin resistance and slow the growth of cancer,. It also states that Milk Thistle will lower Ferritin and that iron-supplement is advised. From aloe to honey, you might be surprised what basic ingredients can help improve breakouts. However, evidence suggests that milk thistle extracts might be useful in the treatment of mood disorders. Store at room temperature away from moisture, heat, and light. Using different formulations together increases the risk of an overdose. Studies have shown a decrease in blood sugar levels and an improvement in cholesterol in. Medical research suggests that milk thistle, combined with traditional treatment, can improve diabetes. Digestion and Depression . Milk thistle. Silymarin: not just another antioxidant. Trigonella foenum-graecum(fenugreek)also is used for this reason. Taken in appropriate doses, oral use of milk thistle appears to be safe. Our website services, content, and products are for informational purposes only. Dupuis ML, Conti F, Maselli A, et al. More research is needed before a standard dosage of milk thistle can be recommended, so check with your healthcare provider. Milk thistle ( Silybum marianum) is an herbal remedy used mainly to protect and detoxify the liver. Milk thistle. Hepatology. Some studies also show milk thistle may help people whose liver is damaged by industrial toxins, such as toluene and xylene. Accessed Oct. 30, 2020. However, the results from studies have been mixed, and not all have found milk thistle extract to have a beneficial effect on liver disease. Certain people should take precautions when using milk thistle, and others may need to avoid it altogether. Neuroprotective potential of silymarin against CNS disorders: insight into the pathways and molecular mechanisms of action. An official website of the United States government. Since milk thistle may lower blood sugar, people with diabetes should check with their doctor before taking the herb as it may make their blood sugar fall too low. Clipboard, Search History, and several other advanced features are temporarily unavailable.Eva Longoria Aperol Spritz, Articles M